基于甲基酸盐和再巩固的灭绝的协同作用使药物成中的中腹前额功能正常化
Ahmet O Ceceli1, Sarah G King1, K Rachel Drury1
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029-5674.
概括
甲基 (MPH) 结合后恢复灭绝 (RE) 可能有助于可卡因成的恢复. 这种方法使与药物线索相关的大脑活动正常化,通过调节药物记忆来潜在地改善戒断.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 成研究 研究成研究
背景情况:
- 与毒品相关的记忆阻碍了成中的戒断.
- 针对腹中中前额叶皮层 (vmPFC) 和杏仁体的标准灭绝疗法表现出有限的成功.
- 后检索灭绝 (RE) 在再巩固过程中增强了记忆更新.
研究的目的:
- 调查多巴胺激动剂甲基 (MPH) 是否可以增强可卡因使用障碍 (CUD) 的RE.
- 检查MPH组合RE在暗示暴露期间对vmPFC活性和杏仁体连接性的影响.
- 评估对后续寻找毒品行为的影响.
主要方法:
- 进行了一项双盲,随机,在受试者内部的临床试验.
- 患有CUD的参与者在提示检索和灭绝之前接受了MPH (20毫克) 或安慰剂.
- 实验室模拟的寻找药物的行为在第二天被测量.
主要成果:
- 在安慰剂下标准灭绝表明vmPFC活性受损,与CUD一致.
- RE和MPH条件显示vmPFC招募增加,RE的影响与安慰剂下寻找药物有关.
- 联合MPH的RE使皮层-边缘处理正常化,绕过vmPFC及其杏仁体连接.
结论:
- 药理学增强的记忆调制,特别是MPH结合的RE,显示了对CUD的承诺.
- 这种方法可能通过向不适应性药物记忆来提供一种新的中药恢复干预策略.
- 需要进一步的研究来探索药理上增强的记忆再巩固的治疗潜力.
相关概念视频
Drug Abuse and Addiction: Pharmacological Phenomena
1.1K
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
1.1K
Desensitization and Tachyphylaxis
3.0K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.0K
Drug Dependence
1.6K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.6K
Attention-Deficit/Hyperactivity Disorder
733
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
733
Drugs Affecting Neurotransmitter Release or Uptake
1.5K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.5K
Combined Effects of Drugs: Synergism
6.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
6.7K


