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Updated: Jan 12, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
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Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry

Published on: July 20, 2016

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KEAP1的KELCH域的基导向站点选择性氨酸生物结合与高价试剂

Christine Marty1, Xinjian Ji2, Stefano Nicolai1

  • 1Laboratory of Catalysis and Organic Synthesis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Ch-1015 Lausanne, Switzerland.

Journal of the American Chemical Society
|November 4, 2025
PubMed
概括

化学家们使用亲和力驱动的反应实现了选择性蛋白质标记. 高价试剂 (EBXs) 与配体相结合,可以精确修改KEAP1,这是一种调节氧化应激的蛋白质.

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Ligand Binding Sites02:40

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
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