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新型菌和PLWH:血清菌抗原查的作用

Özlem Gül¹, Nazife Duygu Demirbaş¹, Ayşe Barış²

¹University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, Infectious Diseases and Clinical Microbiology, Istanbul, Turkey .

Journal of infection in developing countries

|November 4, 2025

概括

血清密码球菌抗原 (CrAg) 查有助于在艾滋病毒感染者 (PLWH) 中早期诊断密码球菌脑膜炎. 虽然CrAg阳性可能发生在症状出现之前,但由于潜在的错误结果,需要仔细评估,即使CD4计数超过100细胞/μL.

科学领域:

传染性疾病传染性疾病
临床微生物学临床微生物学
艾滋病毒医学艾滋病毒医学

背景情况:

血清密码球菌抗原 (CrAg) 查对于早期的密码球菌脑膜炎检测至关重要.
这项研究评估了6年来艾滋病毒感染者 (PLWH) 的CrAg查结果.

研究的目的:

评估血清CrAg查在PLWH中的有用性.
分析与CD4+T细胞计数和临床结果相关的CrAg测试结果.

主要方法:

从具有CD4+T细胞计数<200细胞/μL的PLWH获得的CrAg查数据的回顾性分析.
收集的数据包括人口统计,并发症,CD4+T细胞计数,HIVRNA水平和脑脊液 (CSF) 发现.
描述性统计数据被用于数据分析.

主要成果:

血清crAg测试对99名患者进行,有9人呈阳性结果.
四名crAg阳性患者被诊断患有密码球菌脑膜炎;两人有错误的阳性结果.
一名脑膜炎患者的CrAg为负,一个阳性病例在随访中丢失.

结论:

CrAg阳性可以表明无症状的加密球菌感染.
即使是具有CD4+T细胞计数>100细胞/μL的PLWH,也应该考虑查.
由于潜在的假阳性和假阴性Crag结果,需要仔细解释.

关键词:

这就是CragAg CrAg.密码球菌脑膜炎是什么?艾滋病病毒艾滋病病毒艾滋病病毒抗原是一种抗原.查检查查检查查检查查检查

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