将桃体样本添加到喉抽样中不会提高SARS-CoV-2的检测率 - 这是一项多中心随机对照试验
Benedikte Hartvigsen1, Kathrine Kronberg Jakobsen2, Thomas Benfield3
1Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet - Copenhagen University Hospital, Inge Lehmanns Vej 8, 2100 Copenhagen, Denmark; Copenhagen Academy for Medical Education and Simulation, Ryesgade 53B, 2100 Copenhagen, Denmark.
Diagnostic microbiology and infectious disease
|November 4, 2025
概括
包括口腔桃体在严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 测试的喉拭片中,并没有提高检测率. 然而,这种方法在测试过程中会增加患者的不适.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 临床诊断 临床诊断 临床诊断
背景情况:
- 在全球范围内,喉抽样是SARS-CoV-2分子检测的标准.
- 包括口腔桃体样本在喉抽样中的诊断影响仍然没有研究.
- 在全球范围内已经进行了数十亿次SARS-CoV-2测试.
研究的目的:
- 为了调查是否包括口腔桃体在喉抽样中会影响SARS-CoV-2检测率.
- 评估患者在喉抽时包括 palatine 桃体的不适.
主要方法:
- 在丹麦进行了一项随机对照试验.
- 参与者被随机分配到标准的喉抽样或包括 palatine 桃体的抽样.
- 反转录聚合酶链反应 (RT-PCR) 用于确定SARS-CoV-2的阳性.
主要成果:
- 两组之间没有观察到SARS-CoV-2检测率的显著差异 (29.2%和29.8%).
- palatine tonsil swabbing 的小组报告了显著更高的不适得分.
- 检测的几率比为0.97 (95% CI 0.84;1.13).
结论:
- 将口腔桃体纳入喉抽样并不能提高SARS-CoV-2的检测.
- 包括口腔桃体在内的喉拭片导致患者更大的不适.
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