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在功能性内镜外科手术后,利用双向输送方法优化局部输送到骨髓综合体.

Ruiping Ma1, Siping Sun2, Yusheng Wang3

  • 1Department of Otolaryngology Head and Neck Surgery & Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Institute for Sustainable Industries & Liveable Cities, Victoria University, PO Box 14428, Melbourne, VIC 8001, Australia.

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优化鼻腔药物输送对于具有鼻息肉 (CRSwNP) 的慢性鼻炎至关重要. 调整设备的鼻孔角度显著改善了药物沉积在骨髓综合体 (OMC).

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通过3D打印打印3D打印.双向的药物输送方式计算流体动力学 计算流体动力学离散阶段模型的离散阶段模型功能性内镜鼻外科手术粒子质量分布 粒子质量分布

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科学领域:

  • 生物医学工程 生物医学工程
  • 呼吸系统医学 呼吸系统医学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 患有鼻息肉的慢性鼻炎 (CRSwNP) 由于手术后的复发性疾病,会带来治疗挑战.
  • 药物向后鼻膜,特别是骨骨综合体 (OMC) 输送不充分,有助于CRSwNP复发.
  • 了解气溶动力学是改善鼻内药物沉积的关键,但对复杂解剖学的定量评估是困难的.

研究的目的:

  • 调查设备参数和空气流对鼻内药物沉积的影响,特别是在CRSwNP治疗的OMC中.
  • 开发和验证用于评估鼻药物输送系统的计算模型.
  • 确定最佳策略,以提高药物输送到鼻腔内的目标区域.

主要方法:

  • 在患者特定的鼻腔模型上利用计算流体动力学 (CFD) 模拟.
  • 整合了现实的多聚分散颗粒大小分布和双向传递.
  • 经过验证的模拟结果与使用3D打印鼻子复制品的体外实验相对应.

主要成果:

  • 侧向调整鼻子插入角度显著改善了OMC药物沉积.
  • 颗粒大小≤15.5微米和≥52.5微米的颗粒与中型颗粒相比,显示出更大的OMC沉积.
  • 呼气流量率 (15-45 L/分钟) 与总的 OMC 质量沉积有正相关;鼻孔壁厚度有轻微的影响.

结论:

  • 鼻孔插入方向是优化区域鼻腔药物输送的关键因素.
  • 颗粒大小和空气流动力学在鼻腔内药物沉积中起着微妙的作用.
  • 这项研究为设计更有效的CRSwNP鼻药物输送系统提供了框架.