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Updated: Jan 12, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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一种新的NOTCH2变种导致骨脆弱性

Ernesto Canalis1, Jungeun Yu2, Emily Denker3

  • 1Department of Orthopaedic Surgery, United States of America; Department of Medicine, United States of America; UConn Musculoskeletal Institute, UConn Health, Farmington, CT 06030, United States of America.

Bone
|November 4, 2025
PubMed
概括

一种新的NOTCH2基因突变导致儿童和小鼠的骨脆弱. 这种遗传变化影响骨脆弱性和发育,可能是由于改变了影响骨细胞的Notch信号通路.

关键词:
骨折 骨折 骨折 骨折 在在NOTCH2中.骨质发生不完美症 (osteogenesis imperfecta) 是一个不完美的疾病.病原性变体的病原性变体骨的脆弱性 骨的脆弱性

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