纤维细胞生长因子受体:心血管疾病中的双向调节作用和治疗潜力
Yiming Jiao1, Bowen Sun1, Mengkai Lu2
1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Biochemical pharmacology
|November 4, 2025
概括
纤维细胞生长因子受体 (FGFRs) 在心血管疾病 (CVDs) 中起着复杂的作用. 了解它们的双重调节功能对于开发有效的向疗法来治疗诸如动脉样硬化和高血压等疾病至关重要.
科学领域:
- 分子生物学分子生物学
- 心血管研究研究心血管研究
- 受体氨酸激酶信号传递受体
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因,由复杂的分子机制驱动.
- 纤维细胞生长因子受体 (FGFR) 家族是一个关键的受体氨酸激酶,显著影响心血管生理学和病理学.
- FGFRs调节关键过程,包括血管重塑,炎症,新陈代谢和组织修复,影响各种心血管疾病.
研究的目的:
- 审查FGFRs在心血管疾病的发病过程中的多方面的作用.
- 阐明FGFRs在不同心血管环境中的矛盾双重调节功能.
- 确定针对FGFR信号的治疗效益在心血管疾病中的挑战.
主要方法:
- 文献综述,重点关注心血管疾病中的FGFR信号通路.
- 对调查FGFR参与血管改造和心肌功能障碍的研究进行分析.
- 检查CVD模型中关于FGFRs保护和有害作用的证据.
主要成果:
- FGFRs表现出取决于背景的角色,可能抑制或促进心血管疾病的进展.
- 特定的FGFR信号级联和与其他分子网络的相互作用影响疾病的结果.
- 相互矛盾的治疗效果凸显了FGFRs参与动脉样硬化,高血压,AF和LVH的复杂性.
结论:
- 更深入地了解FGFR信号特异性对于优化心血管疾病治疗策略至关重要.
- 调和FGFRs的保护作用和促进疾病作用是临床应用的一个关键挑战.
- 针对FGFR介导网络的精细治疗方法对于推进心血管疾病管理至关重要.
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