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Updated: Jan 12, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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具有缩酶域交换的工程多基基体立体中心

Leah S Keiser1,2,3, Panarai Primrose Gatenil2,3,4, Yolanda Zhu1,2,3

  • 1Joint BioEnergy Institute, Emeryville, California 94608, United States.

Journal of the American Chemical Society
|November 4, 2025
PubMed
概括

这项研究设计了多基合成酶 (PKSs) 来控制立体化学,成功地在体内产生了所有四种立体同位素. 基因减少酶 (KR) 和基因合成酶 (KS) 域修饰的策略为新药的PKS工程提供了先进的解决方案.

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Wilhelm Rudolph Fittig discovered the pinacol coupling reaction in 1859. It is a radical dimerization reaction and involves the reductive coupling of aldehydes or ketones in the presence of hydrocarbon solvent to yield vicinal diols.
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