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Updated: Jan 12, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Published on: February 25, 2022

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异常的NSUN1活性将C-RNA修饰与ALS/FTD中的TDP-43神经毒性联系起来

Melissa Parra-Torres1, Kumara Dissanayake1, James A Gray1

  • 1Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, UK.

Life science alliance
|November 4, 2025
PubMed
概括

在ALS和FTD中,TDP-43蛋白质功能障碍与异常RNA甲基化有关. NSUN1激活驱动TDP-43病理,这表明m5CRNA甲基化作为治疗点.

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