在Sorex araneus的季节性收缩期间发生的动态代谢和分子变化
William R Thomas1, Cecilia Baldoni2,3, Yuanyuan Zeng4
1Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA; william.thomas@stonybrook.edu liliana.davalos@stonybrook.edu.
Genome research
|November 4, 2025
概括
欧亚大陆的普通鱼经历了德内尔的现象,在冬天缩小,以节省能源. 福克斯信号协调了这种尺寸变化和代谢变化,影响了它们的寿命.
科学领域:
- 动物学 动物学
- 身体生理学 身体生理学
- 分子生物学分子生物学
背景情况:
- 高度的小型哺乳动物经常冬眠以生存冬天.
- 欧亚常见 (Sorex araneus) 呈现德内尔的现象,在冬季缩小,在春季重新生长.
- 德内尔现象背后的代谢和调节机制尚未完全理解.
研究的目的:
- 为了研究在Sorex araneus的Dehnel现象期间的代谢,蛋白质和基因表达的变化.
- 确定协调季节性尺寸变化和鱼代谢的调节途径.
主要方法:
- 在野生的整个季节周期中分析代谢,蛋白质和基因表达特征.
- 同表达模型用于识别协调的基因表达网络.
- 与冬眠物种中已知的机制进行比较.
主要成果:
- 的季节性收缩涉及氧化酸化的调节变化和脂肪酸代谢的增加.
- 观察到葡萄糖生成基因的冬季表达升级.
- 确定FOXO信号作为一个关键的调节器,协调大小和代谢基因表达.
结论:
- 德内尔的现象涉及类似于冬眠的代谢适应,以及葡萄糖生成的独特转变.
- 狐信号在调节季节性尺寸变化和的新陈代谢方面发挥着核心作用.
- 春季FOXO信号的下调可能会影响的寿命.
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