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Updated: Jan 12, 2026

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在mEGFR NSCLCLC中,PKCα作为mTORC1上游的信号守门员

Mojtaba Sadeghi1, Sam B Chiappone1, Mohamed F Salama2

  • 1Stony Brook Cancer Center, Stony Brook University Hospital, Stony Brook, NY, 11794, USA.

Advances in biological regulation
|November 4, 2025
PubMed
概括

蛋白激酶Cαα (PKCα) 通过激活EGFR驱动突变癌症中的AKT-mTORC1通路来驱动肺癌的生长. 这项研究揭示了PKCα信号对瘤存活和增殖的新型依赖.

关键词:
安克拉奇独立增长 (AIG)定点独立生存 (AIS) 是指定点独立生存.发生突变的EGFR.非小细胞肺癌是非小细胞肺癌.在PKCα (PRKCA) 中.蛋白激酶C (PKC) 是一种蛋白激酶.在 mTORC1 的情况下,mTORC1 是

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