一种新的D-sorbitol,甲酸和皮科硫酸肠道清洁溶液的有效性和安全性用于结肠镜检查:一项前性,多中心的随机研究
Seung Yong Shin1, Yoo Jin Lee2, Yunho Jung3
1Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
概括
一种新型的肠道制备溶液 (DAP) 提供了有效和安全的结肠清洗在单剂量. 患者发现这种低体积的选择比传统方法更容易接受和更容易摄入.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠手术 结肠直肠手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 低容量,快速起作用的肠道制剂可以提高患者的坚持和舒适度.
- 目前的肠道制备方法通常涉及大量和分剂方案.
- 需要新的药物来改善结肠镜准备期间的患者体验.
研究的目的:
- 评估一种新的肠道制备溶液的疗效,安全性和患者接受度.
- 溶液中含有D-比醇,甲酸和皮科硫酸盐 (DAP).
- 为了比较DAP (同一天的剂量) 与聚乙烯糖醇加上酸 (PEG+Asc;分剂量).
主要方法:
- 一个前性的多中心随机试验,涉及243名接受结肠镜检查的患者.
- 患者接受了0.46L的DAP或2L的PEG+Asc.
- 通过Harefield清洁量表评估肠道清洁;评估安全性和可接受性.
主要成果:
- 成功的肠道清洗率是相似的:DAP的96.8%,PEG+Asc的96.7% (p=1.000).
- 没有观察到临床或实验室安全参数的显著差异.
- 显著较少的患者报告了难以摄入DAP的情况 (22.1%与81.0%相比;p<0.01),满意度得分更高 (8.71与6.22;p<0.001).
结论:
- 基于DAP的肠道清洗是有效和安全的,减少所需的溶液体积.
- 单剂量DAP制剂对患者来说更容易接受,可能会改善坚持.
- 这种新的解决方案可能会导致更有效的结肠镜检查,因为患者更好地遵守.
更多相关视频
相关概念视频
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
534
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
534
Drugs Affecting GI Tract Motility: Other Laxatives
1.0K
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
1.0K
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
362
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
362
Endoscopic Procedures II: Colonoscopy
599
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
599
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
561
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
561
Drugs for Treatment of Constipation-Predominant IBS
688
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
688


