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Updated: Jan 12, 2026

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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在体内有效编辑RNA基因通过工程化cytidine除氨酶APOBECs与PUF蛋白质融合

Wenjian Han1, Bo Yuan2, Xiaojuan Fan3

  • 1Department of Neurology, Songjiang Research Institute, Songjiang Hospital & MOE-Shanghai Key Laboratory for Children's Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hanwenjian@shsmu.edu.cn.

Nature communications
|November 4, 2025
PubMed
概括

研究人员开发了专业的APOBEC (ProAPOBEC),这是一个新的RNA基编辑平台. 这项技术精确地纠正遗传缺陷,在小鼠模型中显示降低胆固醇和自闭症的治疗潜力.

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