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用CYP3A4抑制剂作为Co-former增强rilpivirine口服生物可用性的共同形态方法

Ashwini R Madgulkar1, Mangesh R Bhalekar2, Maryam S Mulla2

  • 1Department of Pharmaceutics, AISSMS College of Pharmacy, Kennedy Road, Near R.T.O, Pune, Maharashtra, 411001, India. armadgulkar@gmail.com.

AAPS PharmSciTech
|November 4, 2025
PubMed
概括

开发了 rilpivirine 和尼古丁胺的共同形态系统 (CAMS),显著提高了该药物的溶解性和口服生物可用性,以改善艾滋病毒治疗. 这种新的药物输送策略提供了增强的抗逆转录病毒疗法.

关键词:
弗洛里·哈金斯相互作用参数汉森溶解度参数 汉森溶解度参数同形态系统是共形态系统.提高口服生物可用性增强剂里尔皮维林 (rilpivirine) 是一种药物.

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