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Updated: Jan 12, 2026

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells
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人类DICER1热点突变导致miRNA功能损失和增加

David Jee1, Seungjae Lee1, Dapeng Yang1

  • 1Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA.

Nature structural & molecular biology
|November 4, 2025
PubMed
概括

癌症中的DICER1突变破坏了微RNA (miRNA) 处理. 一项新的研究显示,这些突变导致链切换,有利于miRNA-3p加载并增加基因抑制.

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