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Updated: Jan 12, 2026

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通过使用生理学基础的药物动力学模型研究硫转移酶介导的乙inylestradiol的药物相互作用

Harry P Moore1, Kuan-Fu Chen2, Aki T Heikkinen2

  • 1Certara Predictive Technologies, Level 2-Acero, 1 Concourse Way, Sheffield, S1 2BJ, Sheffield, UK. harry.moore@certara.com.

The AAPS journal
|November 4, 2025
PubMed
概括

这项研究扩展了药理动力学模型,以预测与乙烯乙醇 (EE) 和其主要代谢酶SULT1E1.1.的药物相互作用. 模拟表明与齐里塔克斯塔特的潜在相互作用,但不是埃托里可西布.

关键词:
药物相互作用 (DDI) 是一种药物相互作用.在体外-体外抽取 (IVIVE)口服避孕药 (OC) 是一种口服避孕药.基于生理学的药理动力学建模 (PBPK)硫转移酶 (SULT) 是一种

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