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胰岛素格拉在第一种生物类似胰岛素格拉之前和之后的使用和支出:真实世界的数据研究
Jonathan H Watanabe1, Michael W Strand2, Weining Shen3
1Department of Clinical Pharmacy, University of California San Francisco, School of Pharmacy, San Francisco, CA, USA. Jonathan.watanabe@ucsf.edu.
Journal of general internal medicine
|November 4, 2025
概括
引入诸如Basaglar®和Semglee®之类的生物类似胰岛素显著降低了糖尿病患者的支出. 生物类似药的可用性增加了患者获得glargine胰岛素的机会,并产生了大幅度的年度节省,支持采用政策.
科学领域:
- 药物经济学 药物经济学
- 糖尿病管理 糖尿病管理
- 卫生政策 卫生政策
背景情况:
- 胰岛素格拉金 (Lantus®) 是医疗保险D部分的主要支出,直到生物类似药Basaglar® (2016) 和Semglee® (2020) 出现.
- 这项研究是对替代格拉的使用,成本和节省的首次大型卫生系统分析.
研究的目的:
- 评估在引入替代菜之前和之后的菜利用率,成本和节约.
- 为使用insulin glargine的糖尿病患者提供准入和政策决策的信息.
主要方法:
- 追溯性,观察性,纵向性研究设计.
- 对110,659名患有I或II型糖尿病的glargine使用者的分析.
- 检查每日使用的glargine产品 (Lantus®,Basaglar®,Semglee®),支出,以及按年龄类别的储蓄.
主要成果:
- 每月的支出从191美元下降到147美元至158美元后生物类似药的引入.
- 在2012年至2022年期间,Glargine用户从8,541人增加到39,536人.
- 在2022年,每年节省的费用达到19050万美元,患者获得的机会增加.
结论:
- 巴萨格拉®和塞姆格利®生物类似剂的可用性降低了胰岛素格拉金的支出.
- 生物类似药物增加了格拉使用者的数量和治疗效率.
- 这些研究结果支持采用生物类似胰岛素政策,以改善患者获取和节省成本.
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