在失眠中受损的情绪处理:REM睡眠β功率和前皮层激活
Shuo Wang1,2, Yun Tian3, Xinyi Deng4
1Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, 400715, China.
BMC medicine
|November 4, 2025
概括
患有失眠障碍的人表现出改变的情绪处理,与睡眠过度兴奋相关的中间轨道前皮层激活增加. 这表明睡眠障碍与失眠中的情绪失调之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 失眠障碍与情绪失调有关,但其神经支和与REM睡眠β功率等高兴度生物标志物的联系尚不清楚.
- 这项研究研究了失眠障碍 (ID) 中情绪处理的神经基础及其与电脑电图 (EEG) 测量相关性.
研究的目的:
- 在患有失眠障碍 (ID) 的患者中探索情绪处理的神经相关物.
- 调查情绪处理变化与睡眠过度兴奋生物标志物之间的关联,特别是REM睡眠β功率.
主要方法:
- 35名ID患者和34名健康对照 (HC) 在执行情绪匹配任务时接受了EEG和fMRI.
- 分析了行为数据,大脑激活模式和大脑活动与REM睡眠β功率之间的相关性.
主要成果:
- 与HC相比,ID患者在看到快乐的面孔时,表现出更长的反应时间和更大的激活区域,包括右中间轨道前皮层 (mOFC).
- 在ID患者中,在快乐面孔的REM睡眠β功率和右mOFC激活之间发现了显著的负相关性,即使在控制抑郁和焦虑后也是如此.
结论:
- 作为对积极刺激的反应,mOFC激活的增加可能表明ID的情绪调节发生了改变.
- 与睡眠相关的过度兴奋似乎与改变的情绪处理有关,为失眠中情绪失调的神经基础提供了洞察力.
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