全球自身免疫结节病的研究格局:20年图书识别分析 (2005-2025)
Mehmet Ertan Temir1, Gizem Yavaş Temir2
1Department of Clinical Neurophysiology, Neurology, Erzurum City Hospital, Yakutiye, Erzurum, Turkey.
Orphanet journal of rare diseases
|November 4, 2025
概括
这份图书统计分析显示,自免疫结节病 (AN) 在其2021年分类后的研究激增. 主要发现突出了主要的国家,作者和研究主题,强调需要进行更大规模的研究和国际合作,以了解这种罕见的神经病.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
背景情况:
- 自身免疫结节病 (AN) 是一种罕见的免疫介导的神经病,其特征是针对结节和偏节蛋白的自身抗体.
- 在2021年,AN被正式归类为一个独立的实体,导致科学兴趣增加.
- 研究一直专注于神经素-155和接触素-1作为关键的自身抗原.
研究的目的:
- 进行对自免疫节节病 (AN) 研究从2005-2025年进行全面的文献分析.
- 识别AN领域的研究趋势,有影响力的出版物,领先的作者,机构和合作网络.
- 为未来的AN研究方向提供路线图.
主要方法:
- 在科学网络核心集合中使用与AN相关的关键字进行文献搜索.
- 根据定义的标准,包括了109篇原始的英语文章.
- 使用VOSviewer和CiteSpace进行的网络可视化和引文爆发分析;使用SPSS和Microsoft Excel进行的描述性统计和趋势预测.
主要成果:
- 2021年后出版物的显著增加,与AN的正式定义相吻合.
- 法国,德国,西班牙和日本被确定为最具生产力的国家.
- 领先的作者包括Querol Luis,Sommer Claudia和Doppler Kathrin;高度引用的文章集中在病原和抗体概况上,关键词如"神经神经","IgG4"和"自身免疫结节病"占主导地位.
结论:
- 这是AN科学景观的第一个图书统计分析.
- 尽管人们越来越感兴趣,但大规模流行病学研究和随机对照试验存在重大差距.
- 未来的研究应该优先考虑国际合作和基于抗体的分层对AN诊断和治疗.
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