慢性阻塞性肺病患者上肢和下肢功能,认知障碍和抑郁症之间的关系:一个横截面研究
Jin-Zhuan Zhang1, Xiang-Yun Wang, Hong-Jun Ai
1Department of Respiratory Medicine, Kongjiang Hospital, Shanghai, China.
Medicine
|November 5, 2025
概括
慢性阻塞性肺病 (COPD) 的肢体功能不佳与认知衰退和抑郁症有关. 上肢功能指数 (UEFI) 和下肢功能指数 (LEFI) 可能有助于早期发现这些问题.
科学领域:
- 肺部医学 肺部医学
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 慢性阻塞性肺病 (COPD) 经常与四肢功能障碍,认知障碍和抑郁症同时发生.
- 上肢功能指数 (UEFI) 和下肢功能指数 (LEFI) 是经过验证的COPD特异性肢体功能指标.
- 慢性肺炎患者的四肢功能 (UEFI/LEFI) 和认知/情绪状态之间的关系尚未得到广泛研究.
研究的目的:
- 调查UEFI和LEFI评分是否独立预测COPD患者的认知障碍和临床显著的抑郁症状.
- 评估自我报告的上肢和下肢功能以及COPD队列中认知衰退和抑郁症的存在之间的关联.
主要方法:
- 一个单一中心的横截面研究招募了120名稳定的COPD门诊患者 (年龄≥40岁),没有神经肌肉疾病.
- 上肢和下肢功能分别使用UEFI和LEFI进行评估.
- 认知障碍被定义为蒙特利尔认知评估得分<26,中度至重度抑郁症被定义为患者健康问卷-9得分≥10. 用多变量逻辑回归进行分析.
主要成果:
- 35.8%的参与者患有抑郁症,29.2%的人患有认知障碍.
- 在UEFI中每增加1个标准偏差都与认知障碍 (aOR:0.46) 和抑郁症 (aOR:0.48) 的几率降低有关.
- 在LEFI中每增加1个标准偏差都与认知障碍 (aOR:0.65) 和抑郁症 (aOR:0.51) 的几率降低有关.
结论:
- 根据UEFI和LEFI的测量,自我报告的肢体功能独立预测COPD患者的认知衰退和抑郁症.
- 这些发现表明,将UEFI和LEFI纳入常规COPD评估可能有助于早期检测认知和情绪障碍.
- 使用这些功能指数可以指导开发综合康复策略,以全面管理COPD.
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