饮食模式和缺血性中风风险:一个双样本的门德尔随机化研究
Jingya Guo1, Zhi Xi2, Ming Wang2
1Department of Neurology, Zhengzhou University Affiliated Zhengzhou Central Hospital, Zhengzhou, Henan, China.
Medicine
|November 5, 2025
概括
油性鱼,奶酪和红酒等特定饮食可能会降低缺血性中风风险. 高糖和高蛋白饮食可能会增加风险,因此需要进一步研究中风预防策略.
科学领域:
- 营养流行病学 营养流行病学
- 心血管遗传学 心血管遗传学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 饮食和营养显著影响缺血性中风 (IS) 的发展和结果.
- 关于饮食和IS风险的观察性研究往往由于混因素和测量错误导致不一致的结果.
- 门德尔随机化 (MR) 提供了一个强大的方法来推断饮食-IS研究中的因果关系.
研究的目的:
- 调查22种饮食因素与缺血性中风风险之间的因果关系.
- 利用遗传数据来加强饮食和IS之间的关系中的因果推理.
- 确定可能影响IS风险的特定饮食成分.
主要方法:
- 进行了一种双样本的门德尔随机化 (MR) 分析.
- 饮食暴露的遗传仪器来源于英国生物银行全基因组关联研究.
- 对缺血性中风风险的结果数据来自MEGASTROKE联盟,使用反变量加权分析作为主要方法,并进行灵敏度分析.
主要成果:
- 油性鱼类,奶酪,干果,每周红酒和补充剂的消费与降低缺血性中风风险有显著联系.
- 观察到高糖和高蛋白饮食模式与IS风险增加有暗示性关联,尽管这些不能承受多重比较校正.
- 该研究确定了特定的饮食因素,这些因素可能对IS产生保护作用.
结论:
- 这项孟德尔随机化研究提供了证据,支持与食用油性鱼,奶酪,干果,红酒和补充剂相关的缺血性中风风险降低.
- 含糖或蛋白质高的饮食模式可能与缺血性中风的风险增加有关.
- 结果强调了饮食管理在中风预防中的作用,并突出了未来研究的领域.
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