美国成年人中的全静电负荷和喘之间的关联:全国性的横截面研究
Jinzhi Zhang1, Wenjie Wang2, Qing Miao1
1Respiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Medicine
|November 5, 2025
概括
慢性压力,以全静电负荷 (AL) 衡量,与美国成年人中更高的喘患病率有关. 这种关联在女性和弱势群体中更强,这表明压力管理可以减少喘负担.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 心理神经免疫学 心理神经免疫学
背景情况:
- 慢性心理社会压力被怀疑有助于喘的发展.
- 将生理压力标志物与喘患病率联系起来的大规模人口数据有限.
- 静态负荷 (AL) 量化了由慢性压力引起的多系统生理失调.
研究的目的:
- 调查美国成年人的全静态负荷 (AL) 和喘患病率之间的联系.
- 探索人口和社会经济因素对效果的改变.
主要方法:
- 国家健康和营养检查调查 (NHANES) 分析2005-2010年美国15533名成年人的数据.
- 使用8个生物标志物 (心血管,代谢,炎症) 计算静态负荷指数 (ALI).
- 对共变量进行调整的调查加权后勤回归,ALI分类为≤1,2,≥3.
主要成果:
- 一个单位的ALI增加与13%更高的喘几率相关 (aOR:1.13,95%CI:1.08-1.18).
- 与ALI ≤1 (aOR: 1.45,95%CI: 1.25-1.69) 相比,ALI ≥3的个体患喘的几率高出45%,显示出剂量反应趋势.
- 在女性和社会经济地位较低的人群中,ALI与喘的关联显著更强 (p-相互作用 = 0.01).
结论:
- 累积的生物压力,按AL指数,与美国成年人中喘患病率的增加有显著关联.
- 这些发现突出了弱势群体,特别是妇女和社会经济弱势群体.
- 将AL纳入喘风险评估并解决健康的社会决定因素可能会减少喘负担.
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