相关实验视频

Updated: Jan 12, 2026

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

耳和关节疾病之间是否存在遗传相关性? :一个双样本的门德尔随机化研究

Xiangyu Ma¹, Wenjing Tang², Mingna Huang³

¹Department of Stomatology, Chongqing General Hospital, Chongqing, China.

|November 5, 2025

概括

这项研究发现,频繁的耳声可能会降低关节障碍 (TMD) 肌肉疼痛的风险,特别是与纤维肌痛相关的疼痛. 然而,在TMD和发展耳之间没有发现因果关系.

科学领域:

神经学神经学
遗传学是一个遗传学.
流行病学流行病学

背景情况:

耳和关节障碍 (TMD) 经常同时发生,但观察性研究显示相关性不一致.
了解 tinnitus 和 TMD 之间的因果关系对于有效的临床管理至关重要.

研究的目的:

通过使用强大的遗传方法来调查声和TMD之间的潜在双向因果关系.
为了澄清连接耳和关节疾病的遗传倾向.

主要方法:

采用双样本的门德尔随机化 (MR) 方法.
从全基因组关联研究 (GWAS) 中利用单核酸多态 (SNPs) 作为工具变量.
遵守STROBE-MR研究质量评估指南.

主要成果:

显著的证据表明,频繁的耳声 (大多数或所有时间都存在) 与TMD肌肉疼痛的风险降低有关,特别是与纤维肌痛相关的疼痛 (OR = 0.239,P = 0.0057).
没有观察到其他 tinnitus 频率和增加 TMD 风险之间的显著相关性.
反向MR分析表明,TMD暴露对发展耳的风险没有因果关系.
敏感性分析证实,没有显著的水平形和异质性.

结论:

这项研究提供了基因证据,支持高频率耳与与纤维肌痛相关的TMD肌肉疼痛风险降低之间的关联.
进一步研究潜在的疾病机制是有必要的,以充分阐明耳与TMD之间的复杂关系.

关键词:

门德尔的随机化这种因果关系是因果关系.基因组学就是基因组学.部部疾病部部疾病耳声 (tinnitus) 是一种耳声.

更多相关视频

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

Taste Exam: A Brief and Validated Test

Taste Exam: A Brief and Validated Test

Published on: August 17, 2018

相关概念视频

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Regression Toward the Mean

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...

McNemar's Test

McNemar's Test

McNemar's Test is a nonparametric statistical test used to determine if there is a significant difference in proportions between two related groups when the outcome is binary (e.g., yes/no, success/failure). It is beneficial when we have paired data, such as pre-test/post-test designs, where the same subjects are measured under two different conditions. The test is named after the statistician Quinn McNemar, who introduced it in 1947. It is commonly used in situations where subjects are...