末期癌症患者的预后因素和基于名录的生存预测:一项回顾性研究
Weiwei Gui1, Chunhui Ding2, Lei Xu3
1Department of Oncology of Hospital, Nanjing Tech University, Nanjing, China.
Medicine
|November 5, 2025
概括
预测末期癌症患者的生存率是复杂的. 关键因素包括治疗意愿,呼吸不良,血清尿素,白蛋白和中性粒细胞,而不是传统的指标,如瘤类型或年龄.
科学领域:
- 在瘤学瘤学.
- 医学预测 医学预测
背景情况:
- 对于末期癌症患者的预后知之甚少.
- 确定准确的预测因素对于临床管理至关重要.
研究的目的:
- 为了确定终末期癌症的关键预后因素.
- 开发和验证患者生存的视觉预测模型 (nomogram).
主要方法:
- 对末期癌症患者 (2011-2020年) 的回顾性分析.
- 数据分为培训 (n=193) 和验证 (n=85) 队列.
- 分析临床和实验室数据以确定预后因素并构建一个名ogram.
主要成果:
- 传统因素 (瘤类型,阶段,年龄,ECOG状态) 并不是显著的预测因素.
- 确定了重要的预后因素:接受治疗的意愿,呼吸不良,血清尿素,血清白蛋白和中性粒细胞数量.
- 开发并验证了一种高度准确和可靠的名图.
结论:
- 末期癌症的生存预测依赖于非传统因素.
- 开发的诺莫图谱为预测患者存活率的临床应用提供了一个实用的工具.
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