在小儿科队列中同时出现的腺炎和皮肤病:回顾性病例系列
Vince Wu1,2, Irene Lara-Corrales1, Cathryn Sibbald1
1Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Journal of cutaneous medicine and surgery
|November 5, 2025
概括
患有补性腺炎 (HS) 和性皮肤炎 (PG) 的儿科患者表现出明显的炎症模式. 对HS的手术可能会在这种罕见的重叠群体中引发PG的发展.
科学领域:
- 皮肤病学 皮肤病学
- 儿科医学 儿科医学
- 炎症性疾病 炎症性疾病
背景情况:
- 补腺炎 (HS) 和性皮肤炎 (PG) 是慢性中性恋性皮肤病.
- 它们在儿童中同时发生的情况没有得到充分的证据.
研究的目的:
- 描述患有同时出现HS和PG的儿科患者的临床特征,重叠和治疗.
- 在这个人群中识别潜在的风险因素和炎症标志物.
主要方法:
- 儿科患者 (3-17岁) 被诊断出HS和PG的回顾性病例系列.
- 收集的数据包括人口统计,临床表现,实验室结果,遗传学和治疗方法.
- 提取的电子病历数据的描述性分析.
主要成果:
- 5.7%的儿科HS患者同时患有PG,HS发病时间早于PG.
- 肥胖症 (71.4%) 和结合性 (42.9%) 等并发症很常见.
- 升高的ESR预测了HS的严重程度;在一些患者中发现了自身炎症基因变异和PASH/PAPA综合征标准.
- 在4个案例中,HS的手术干预在3个案例中先于手术部位的PG发展.
结论:
- 患有HS-PG的儿科患者可能代表一个独特而严重的炎症子集.
- 需要进一步的研究来确定风险因素,生物标志物和最佳治疗方法.
- 该研究强调了HS手术治疗和随后的PG发展之间的潜在联系.
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