优性双极性障碍的特定领域认知功能:系统性审查和元分析
Samuel Swidzinski1, Dimosthenis Tsapekos1, Pricilla Swidzinska1
1Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Psychological medicine
|November 5, 2025
概括
情感双极性障碍 (BD) 与包括记忆和执行功能在内的多个领域的显著认知障碍有关. 这些缺陷影响日常功能,并建议未来治疗干预的目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 情感双极性障碍 (BD) 的特点是影响一般和特定领域的认知障碍.
- 这些认知缺陷与BD患者的职业和社会功能较差有关.
研究的目的:
- 系统地回顾和元分析在euthymic双极性障碍 (BD) 中的认知功能.
- 为了确定特定的认知领域受到了euthymic BD的影响,并探索潜在的影响因素.
主要方法:
- 在Embase,Medline和PsycInfo数据库中进行了全面的文献搜索,截至2024年6月.
- 用元分析和元回归来分析认知数据,包括先发病的智商,人口统计和临床变量.
- 研究的质量,异质性和出版偏差均使用已建立的统计方法和程序进行评估.
主要成果:
- 分析包括了75项研究,其中包括4,404名患有BD的个人和4,037名健康对照 (HC).
- 在BD中,在一般功能,口头记忆,执行功能,视觉空间记忆,注意力/处理速度和工作记忆方面观察到显著的认知障碍.
- 虽然人口和临床因素的相关性有限,但高等教育与语言记忆障碍的相关性较小.
结论:
- 优性双极性障碍 (BD) 与广泛的认知缺陷有关,突出了干预开发的关键领域.
- 认知表现的不明原因变异需要进一步研究,使用更大的数据集和个人级别的数据分析.
相关概念视频
Bipolar Disorder
584
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
584
Mania and Antimanic Drugs: Overview
522
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
522
Depression: Overview
735
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
735
Depressive Disorders: MDD and Dysthymia
547
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
547
Depressive Disorders: Etiology
406
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
406
Antidepressant Drugs: MAOIs and Other Agents
761
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
761


