大人的希尔施普朗格病的长期影响:元分析和患者水平回归研究
Marta de Andres Crespo1, Cornelia Byström2, Athanasios Tyraskis3
1Institute of Child Health, University College London, London, UK.
患有赫施普朗格病 (HS) 的成年人经历了更高的便秘和污染率,影响了他们的生活质量. 女性,更长段的HS和重复手术患者报告的结果较差.
科学领域:
- 胃肠病学 胃肠病学
- 儿科手术 儿科手术
- 生活质量研究 研究 生命质量研究
背景情况:
- 关于希尔施普朗格病 (HS) 的长期结果的单一中心研究越来越多.
- 需要对HS患者的成人功能结果进行全面的系统审查.
研究的目的:
- 系统地审查HS成年人的长期肠道,泌尿和性功能,生育能力和生活质量.
- 为了将临床和外科变量与功能结果相关联.
主要方法:
- 在PROSPERO注册的2025年7月为止的英语文学系统审查.
- 包括报告儿童期 (≥16岁) 以后功能结果的研究.
- 与健康对照人群相比,患者级数据分析,包括肠功能得分,GI生活质量指数和SF-36.
主要成果:
- 包括53个手稿;HS患者表现出较高的便秘 (OR 9.27) 和污垢 (OR 2.76) 与对照.
- 在HS患者中,较低的GI生活质量指数得分 (MD -5.21) 和身体功能 (MD -6.30).
- 较长段疾病和重复手术与肠功能差相关;女性和较长段疾病患者报告了较低的QoL.
结论:
- 女性,更长段HS患者,以及接受重复手术的患者,生活质量较差的风险更高.
- 系统性审查突出显著的长期功能缺陷和生活质量影响HS的成年人.
- 对于特定的患者亚组,需要进一步的研究和有针对性的干预措施.
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