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Updated: Jan 12, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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对于抗体 - 药物合物的谷氨可切割的阿佐烯链接剂

Mia Kapun1, Roshan Patel1, Mahri Park1

  • 1Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. spring@ch.cam.ac.uk.

Chemical communications (Cambridge, England)
|November 5, 2025
PubMed
概括

研究人员开发了一种新的谷氨可切割连接器,用于抗体-药物合物 (ADC). 这种连接器使得癌细胞中的药物有效释放,同时在体内保持稳定,显示了针对癌症治疗的希望.

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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Conjugation, a key component of phase II biotransformation reactions, is a vital process in drug detoxification. It involves transferring endogenous substances like glucuronic acid, sulfate, and glycine to drugs or their metabolites formed in phase I reactions. These conjugation reactions, often catalyzed by specific enzymes, transform potentially harmful metabolites into inactive, water-soluble forms easily excreted in urine or bile. By enhancing polarity and eliminating pharmacological...
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Antibody Structure01:10

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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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