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吸烟和COPD中的细胞外铁和肺微生物组
Claire Healy1, Christina Campbell2,3, Katherine Hoffman4
1School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
ERJ open research
|November 5, 2025
概括
吸烟者的呼吸道铁和铁结合蛋白增加,特别是COPD患者,与肺微生物组的特定变化有关. 这些发现表明,慢性阻塞性肺病中铁失调和微生物组成之间存在联系.
科学领域:
- 微生物学 微生物学
- 肺部医学 肺部医学
- 主体-微生物组的相互作用
背景情况:
- 肺微生物组中的微生物利用铁获取策略来生存.
- 吸烟者的支气管洗液 (BALF) 中铁含量和相关蛋白质的升高与COPD的严重程度相关.
研究的目的:
- 研究呼吸道铁量增加与有或没有COPD的吸烟者呼吸道微生物组的变化之间的关联.
主要方法:
- 来自181名SPIROMICS参与者的BALF的16S rRNA基因测序.
- 测量BALF铁,费里 (前费里) 和脂-2 (LCN-2) 的含量.
- 微生物组成和与铁相关的标记物之间的相关性分析.
主要成果:
- 铁含量和BALF微生物多样性之间没有总体关联.
- 在从未吸烟的人中观察到具有低前费里的特定种类丰富,在吸烟者中观察到具有高铁的吸烟者.
- 在COPD患者中,根据铁,前费里丁,LCN-2水平和恶化史,特定的类型 (Bacteroidetes-OTU0063,Streptococcus,Leptotrichia,Moraxella) 被丰富.
结论:
- 气道铁和铁结合蛋白可能会影响COPD患者下呼吸道中共生和致病微生物的存在.
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