当疗法变得有毒时:通过公共质谱数据库识别的有毒化物的案例报告
Yuyan Lei1,2, Qin Yi3, Junli Lu1
1Phase I Clinical Trial Laboratory, The Second Nanning People's Hospital, Nanning, Guangxi, China.
Frontiers in medicine
|November 5, 2025
概括
从草药葡萄酒中意外中毒是由于植物识别错误而造成的风险. 质谱仪和光谱数据库使得在案例报告中能够快速识别有毒的藻类化物.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 阿科尼丁是来自*Aconitum brachypodum*的有毒化物,在中国传统医学中使用.
- 在亚洲,意外的素中毒很普遍,通常是由于与类似的植物混为一谈,如Cistanche deserticola.
- 这一案例凸显了自制草药药酒的危险性.
研究的目的:
- 报告一例由于意外摄入草药葡萄酒而发生的阿科尼丁中毒病例.
- 证明质谱学和大规模光谱数据库对快速毒性物质查的有用性.
- 提出一种用于识别未知的毒剂的新方法.
主要方法:
- 一个54岁的男性在饮用草本葡萄酒后出现了中毒症状的病例报告.
- 对患者的草本葡萄酒样本进行毒理分析.
- 超高性能液态色谱四极点飞行时间质谱学 (UHPLC-QTOF-MS) 分析.
- 利用全球自然产品社会 (GNPS) 谱图书馆进行物质识别.
主要成果:
- 在草药葡萄酒中鉴定了几种阿科尼类,包括因达科尼,尤纳科尼,塔利塔山胺和查斯曼.
- 这标志着第一个使用大型公共质谱数据库快速查虫中毒的报告.
- 分析方法有助于快速识别导致中毒的有毒化合物.
结论:
- 意外摄入受污染的草药产品对健康构成重大风险.
- 质谱与广泛的光谱数据库相结合,为中毒病例中的毒素快速识别提供了强大的工具.
- 这种方法为调查无法解释的中毒和确保患者安全提供了有价值的方法.
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