通过内镜兼容的动态显微镜光学连贯性断层扫描对人类呼吸道进行成像
Cornelia Holzhausen1,2, Hinnerk Schulz-Hildebrandt2,3,4, Martin Ahrens2,3
1Institute of Anatomy, University of Lübeck, Lübeck, Germany.
Frontiers in medicine
|November 5, 2025
概括
动态对比光学连贯断层扫描 (dmOCT) 与内镜成像相结合,可提供人类呼吸道组织的高分辨率可视化. 这种技术显示了未来在肺部疾病诊断中体内虚拟活检的潜力.
科学领域:
- 肺部医学 肺部医学
- 医疗成像医学成像
- 光学一致性断层扫描技术
背景情况:
- 显微镜对于肺部疾病的诊断至关重要,传统上需要组织活检.
- 微观光学相干断层扫描 (mOCT) 提供了没有标记器的高分辨率成像.
- 动态对比光学连贯性断层扫描 (dmOCT) 增强了呼吸道组织的可视化.
研究的目的:
- 为了评估dmOCT与人类肺组织内镜成像相结合.
- 为了将dmOCT图像与传统组织学进行比较.
- 评估成像时间是否可以在不影响图像质量的情况下缩短.
主要方法:
- 切除的人类肺组织被扫描使用一个定制的内镜光学用dmOCT.
- 将dmOCT图像与同一组织的组织学部分进行比较.
- 系统地减少了成像采集时间,以评估图像质量.
主要成果:
- 内镜dmOCT可视化了人类呼吸道上皮和亚上皮组织,包括光滑肌肉和腺体.
- 该技术检测到病理变化,如炎症,底层膜加厚,上皮损伤和 carcinoma in situ.
- dmOCT成功地区分了各种人类肺癌形态,即使在缩短的获取时间 (0.054秒) 中也保持了对比度.
结论:
- 内镜dmOCT可以实现诊断图像质量和速度,用于潜在的体内虚拟活检.
- 这项技术对未来肺部疾病的非侵入性诊断具有前景.
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