用一个实用的框架来导航结直肠癌查的不断变化的格局:对现有和新兴技术进行全面分析,以便明智地做出决策
Michael Sapienza1, Cheryl Davis2, Mathieu Boudes2,3
1Colorectal Cancer Alliance, Washington, DC, United States.
Oncology reviews
|November 5, 2025
概括
选择合适的结直肠癌 (CRC) 查测试是复杂的,由于新技术. 本综述提供了一个框架,帮助患者和医生根据性能,患者因素和成本选择最佳的CRC查方法.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 结直肠癌 (CRC) 查领域正在随着新技术的发展而迅速发展.
- 缺乏对比研究阻碍了对CRC查测试的知情选择.
- 这需要对CRC查进行全面的审查和决策框架.
研究的目的:
- 审查现有和新兴的CRC查技术.
- 开发一个实用的框架,为知情的CRC查测试选择.
- 帮助临床医生和患者导航各种CRC查选项.
主要方法:
- 对CRC查方法的系统文献综述:结肠镜检查,便免疫化学测试 (FIT),多目标便DNA (mt-sDNA),下一代mt-sDNA,多目标便RNA (mt-sRNA) 和基于血液的测试.
- 总结了表现,坚持,后续结肠镜检查率,可访问性和成本.
- 制定了基于五个关键维度的决策框架.
主要成果:
- 在测试性能,患者遵守性和实施因素方面存在显著差异.
- 基于血液的测试显示出患者接受的希望,但在早期阶段的敏感性较低.
- 制定了一个全面的框架来评估CRC查选项.
结论:
- 开发的框架有助于医疗保健提供者和患者提供个性化的CRC查建议.
- 该框架考虑了测试性能,患者因素,坚持,成本和查间隔.
- 随着新的CRC查技术的出现,需要进一步的验证和更新.
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