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在癌症中,非编码RNA媒介调节髓衍生的抑制细胞

Kengjun Luo¹, Ying Xu^2,3, Jiahao Chen¹

¹Department of General Surgery, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212000, People's Republic of China.

Cancer management and research

|November 5, 2025

概括

非编码RNAs (ncRNAs) 调节瘤中的髓质衍生抑制细胞 (MDSCs). 针对这些ncRNAs提供了一种策略,通过破坏MDSC介导的免疫抑制来增强抗瘤免疫力.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
癌症研究癌症研究

背景情况:

骨髓系衍生抑制细胞 (MDSCs) 是瘤微环境免疫抑制活动的关键调节者.
非编码RNAs (ncRNAs),包括miRNAs,lncRNAs和circRNAs,越来越多地被认为是MDSC生物学的关键调节者.
MDSCs对于瘤免疫逃避和进展至关重要.

研究的目的:

审查目前对ncRNAs如何调节MDSCs的理解.
探索ncRNAs影响MDSC招募,分化和功能的机制.
讨论针对癌症治疗的ncRNAs的治疗潜力.

主要方法:

关于ncRNAs和MDSCs的研究的文献综述.
在MDSC中由ncRNAs调节的信号通路的分析 (例如,STAT3,NF-κB,PI3K/AKT).
检查ncRNAs的表观遗传和转录后调节作用.

主要成果:

ncRNAs通过调节关键信号通路,密切参与MDSC调节.
ncRNAs通过表观遗传修饰,转录后调节和基因网络微调来控制.
对ncRNAs的失调有助于MDSC介导的癌症免疫抑制.

结论:

ncRNAs是MDSC功能和免疫抑制的关键调节者.
准ncRNAs是一个有希望的基于RNA的策略,可以破坏MDSC活动并增强抗瘤免疫力.
需要进一步的研究,以解决治疗应用的传递,稳定性和非目标效应方面的挑战.

关键词:

在MDSCs中.这种ncRNAsRNAs.瘤是一个瘤.瘤免疫力免疫力瘤微环境是一个微环境.

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