含糖饮料和高尿血和痛风的风险:一个元分析
Yuejie Lu1, Yinuo Wang2, Renjie Huang3
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
含糖饮料 (SSB) 的消费显著增加了高尿血和痛风的风险. 与女性相比,这些风险在男性中特别高.
科学领域:
- 代谢健康 代谢健康
- 营养流行病学 营养流行病学
- 痛风病变的发生因子
背景情况:
- 超尿血和痛风与饮食有关,重点是果糖和含糖饮料 (SSB).
- 之前的研究表明了潜在的关联,但需要全面的元分析来澄清这些关系.
研究的目的:
- 进行一项元分析,调查含糖饮料 (SSB),果糖和痛风和高尿血风险之间的关联.
- 探索基于性别的潜在风险差异.
主要方法:
- 按照PRISMA的指导方针,系统地搜索PubMed,EMBASE和Cochrane图书馆的文献.
- 包括22项观察性研究,涉及235,790名参与者.
- 使用随机/固定的效应模型,并对性别进行子组分析,以95%的置信区间 (CI) 聚合调整的赔率比率 (OR).
主要成果:
- 摄入SSB显著增加了高尿血症 (OR=1.33) 和痛风风险 (OR=1.21).
- 果糖消费与痛风风险有很强的关联 (OR=1.66),但与高尿素血症 (OR=1.12) 不一致.
- 与女性相比,男性的SSB (OR=1.37) 和果汁 (OR=1.15) 的高尿血风险较高.
结论:
- 含糖饮料的消费是高尿血和痛风的重要危险因素.
- 在男性中,SSB与这些疾病之间的关联更为明显.
- 进一步研究果糖代谢及其在痛风发展中的特殊作用是有必要的.
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