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循环瘤细胞:癌症进展的指标,可塑性和治疗效用

Tamás Richárd Linkner¹, Zsófia Brigitta Nagy¹, Alexandra Kalmár¹

¹Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

Pathology oncology research : POR

|November 5, 2025

概括

循环瘤细胞 (CTC) 是癌症传播的关键. 本综述探讨了CTCs,表皮细胞转移到介质细胞 (EMT),癌症干细胞 (CSCs),可塑性和衰老,以寻找新的癌症生物标志物和治疗方法.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

循环瘤细胞 (CTC) 是癌症转移和进展的罕见但至关重要的指标.
作为单个细胞或群体存在的CTC提供了对瘤演变的非侵入性见解.
CTC集群比单个CTC具有更高的致癌潜力.

研究的目的:

审查CTC生成,生物学和生存的动态生物过程.
探索表皮细胞到介质细胞过渡 (EMT),癌症干细胞 (CSCs),细胞可塑性和CTC中的衰老的作用.
阐明CTCs对瘤异质性的贡献,并确定新的治疗点.

主要方法:

文献审查侧重于CTC和相关的生物过程.
分析EMT,CSC,可塑性和CTC中的衰老之间的相互作用.
探索CTCs在癌症传播,进展和治疗耐药性的作用.

主要成果:

EMT增强了CTC的运动性,侵入性和免疫逃避.
细胞可塑性允许CTC适应微环境并抵抗治疗.
瘤中枢细胞有助于瘤的启动和自我更新,通常通过EMT或脱差生成.
在CTC中衰老可能是可逆的,促进休眠和转移性重新激活.

结论:

了解CTCs,EMT,CSCs,可塑性和衰老的复杂生物学对于推进癌症研究至关重要.
这些过程对瘤异质性和转移潜力作出了重大贡献.
进一步的见解可能会导致新的生物标志物和固体瘤的治疗策略.

关键词:

在EMT中,EMT是EMT.癌症癌症癌症癌症癌症循环中的瘤细胞.液体活检活检液体活检衰老是一种老化.

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