抗微生物涂层有效地在表面上禁用多药耐药的Candidozyma auris
Sabine Poelzl1, Eva Zarschenas1, Rozita Nokhbehzaeim1
1Diagnostic and Research Institute for Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
Frontiers in microbiology
|November 5, 2025
概括
冠状腺菌 (Candida auris) 是一种多抗药性真菌,在医疗保健中构成重大威胁. 抗微生物表面,特别是那些带有,铜或抗微生物漆的表面,有效地降低了其在表面上的生存率.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 材料科学 材料科学 材料科学
背景情况:
- 黄是一种多药耐药的真菌,会引起疫情爆发,特别是在医疗保健领域.
- 它在表面上的持久性和抗真菌药物的耐药性需要替代的控制策略.
- 抗微生物材料提供了一种有希望的方法来减少病原体在表面上的生存.
研究的目的:
- 评估Candida auris在各种常见和专用表面上的生存和消除.
- 评估抗微生物表面修饰对C. auris. 的有效性.
- 确定Candida albicans是否可以作为C. auris表面生存研究的合适模型生物.
主要方法:
- 采用ISO 22196:2011标准来测试表面的有效性.
- 测试使用C. auris和C. albicans的参考菌株 (DSMZ),以及三个临床C. auris分离物进行了测试.
- 表面材料包括参考材料,和铜组合,以及抗菌漆.
主要成果:
- 坎迪达阿尔比坎斯 (Candida albicans) 证明了其适用性,作为C. auris的模型生物.
- 没有抗微生物添加剂的表面对C. auris没有有效性.
- 和铜的组合在24小时后实现了C. auris的3 log10减少.
- 抗菌漆是最有效的,在1小时内显著降低了真菌生存率.
结论:
- 抗微生物表面修饰是控制关键医疗环境中的Candida auris的有效工具.
- 和铜组合和抗菌漆显示出在减少C. auris污染方面具有显著的潜力.
- 这项研究验证了C. albicans作为评估C. auris表面生存的可靠模型.
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