基于乳酸细菌的牙膏对口腔健康的有效性:系统性审查和元分析
1Department of Dental Hygiene, Daejeon Health University, Daejeon-si, Republic of Korea.
Frontiers in oral health
|November 5, 2025
概括
乳酸细菌 (LAB) 牙膏可以有效地减少斑块和牙炎症. 持续使用至少六个月显示出显著的牙周益处,并降低了Streptococcus mutans水平.
科学领域:
- 口腔健康 口腔健康
- 微生物学 微生物学
- 牙周病学 牙周病学
背景情况:
- 乳酸细菌 (LAB) 具有有益于口腔健康的抗菌和免疫调节特性.
- 益生菌越来越多地被整合到口腔护理产品中,需要对临床疗效进行评估.
- 本研究评估了基于LAB的牙膏在改善口腔健康结果方面的有效性.
研究的目的:
- 系统地审查和元分析基于LAB的牙膏的临床疗效.
- 评估基于LAB的牙膏对斑块指数,牙指数,探针上的出血,探针口袋深度和临床附着水平的影响.
- 评估口腔微生物群组成的变化,特别是Streptococcus mutans水平.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括随机对照试验 (RCT) 评估益生菌,益生菌,共生菌或后生菌牙膏.
- 从五个数据库中提取了主要结果 (PI,GI,BOP,PPD,CAL) 和次要结果 (微生物群变化) 的数据.
主要成果:
- 四个RCT的元分析显示,3个月后显著减少斑块 (MD = -0.64) 和BOP改善 (MD = -1.49).
- 在牙周炎患者的≥6个月的干预表明PPD显著减少 (MD = -1.32) 和CAL改善 (MD = -0.79).
- 在多项研究中观察到Streptococcus mutans水平的显著降低.
结论:
- 基于LAB的牙膏在斑块控制和牙炎症方面具有显著的益处.
- 研究之间的大量异质性需要谨慎地解释影响估计.
- 突出了Lactobacillus paracasei菌株的持续益处和持续使用 (≥6个月) 对于牙周改善的需要.
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