相关实验视频

Updated: Jan 12, 2026

Noninvasive Intratracheal Lipopolysaccharide Instillation in Mice

Noninvasive Intratracheal Lipopolysaccharide Instillation in Mice

Published on: March 31, 2023

通过在家中机械通风患者的长期乳酸酶ibacillus rhamnosus疗法进行免疫调节

Kamila Szyller¹, Grazyna Mlynarczyk², Beata Mlynarczyk-Bonikowska³

¹NZOZ Marusza Clinic, Warsaw, Poland.

MicrobiologyOpen

|November 5, 2025

概括

在家用机械通风的患者中补充Lacticaseibacillus rhamnosus GG (LGG) 增加了关键的免疫标志物,如IL-2和IFN-γ. 这表明LGG可能会增强抗感染免疫力,并降低这一脆弱人群的感染风险.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
呼吸系统医学呼吸系统医学

背景情况:

益生菌调节免疫系统,但它们对家庭机械通风 (HMV) 患者的影响尚不清楚.
肝炎患者容易感染,因此需要采取加强免疫防御的策略.

研究的目的:

研究Lacticaseibacillus rhamnosus GG (LGG) 口服补充剂对HMV患者鼻腔微生物群和免疫参数的影响.
评估LGG在这个患者群体中的安全性和潜在的免疫调节作用.

主要方法:

31名HMV患者在3个月的益生菌洗后,接受了LGG (8 × 10^9 CFU/天) 6个月.
鼻和血液样本在基线,3个月和6个月收集.
评估鼻腔微生物群,Th1/Th2平衡,以及IL-2,IL-4,IL-5,IL-10,TNF-α和IFN-γ的水平.

主要成果:

观察到IL-2 (在3个月和6个月) 显著增加,IFN-γ (在3个月) 和IL-4 (在6个月) 暂时增加.
IFN-γ/IL-10比率在3个月后增加,表明转向促炎反应.
没有检测到鼻腔细菌菌群或其他测量的细胞因子的显著变化;在研究期间不需要抗生素治疗.

结论:

在HMV患者中,LGG补充似乎是安全的,并且耐受良好.
升高的IL-2和IFN-γ表明增强了抗感染免疫力,而增加的IL-4可能会调节炎症.
LGG可能是一种有价值的辅助疗法,可降低感染风险并改善HMV患者的治疗结果.

关键词:

牛奶的乳酸酶ibacillus rhamnosusus的使用方法乳杆菌 rhamnosusus 的乳杆菌.细胞因子细胞因子免疫力是一种免疫力.免疫学免疫学免疫学它们包括interleukins.机械通风机械通风机械通风

更多相关视频

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Published on: July 11, 2016

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

相关概念视频

Acute Respiratory Failure-V

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...

Pneumonia V: Nursing management and Prevention

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....