持续释放玻尿酸片的方法依赖的释放动力学:使用daisy II化器和连续人工唾液系统进行的比较研究
Gurbuz Comak1, Elizaveta Trofimushkina1
1Department of Chemical Engineering, Mersin University, Mersin, Türkiye.
Drug development and industrial pharmacy
|November 5, 2025
概括
在2%的度下,甘草 (GA) 提供了最稳定的持续释放特征,用于兽医玻尿酸片. 与其他系统相比,Ankom Daisy II化器在预测体外释放行为方面表现出卓越的准确性.
科学领域:
- 制药科学 制药科学
- 兽医药物递送 兽医药物递送
- 材料科学 材料科学 材料科学
背景情况:
- 从持续释放配方中准确预测药物释放对于兽医至关重要.
- 溶解测试中的方法依赖的变化可能会影响体外数据的可靠性.
- 了解这些变异对于开发适用于反动物的经济高效和可持续的药物输送系统至关重要.
研究的目的:
- 为了比较使用不同药物结合剂的持续释放玻尿酸片的溶解动力学.
- 评估两种不同的实验设置 (连续流动的人工唾液装置与安科姆 Daisy II化器) 对释放行为解释的影响.
- 评估实验条件如何影响药物释放的动力模型.
主要方法:
- 作为结合剂的粉,聚烯 (PVP) 或木木 (GA) 的不同度 (1%或2%) 的玻尿酸片的配方.
- 使用连续流动的人工唾液系统和安科姆戴II化器与真正的液进行溶解测试.
- 颗粒形态,颗粒大小,散密度和机械强度的表征;使用标准模型进行动力分析,并通过R2和AIC参数进行评估.
主要成果:
- 结合剂类型和度显著影响了药物释放概况:粉显示出快速溶解,PVP中度释放,GA延长,稳定释放.
- 安科姆戴II化器在溶解动力学方面产生了更强的模型相关性.
- 2%的GA配方表现出最好的模型匹配 (R2 = 0.9909,AIC = -71.08),表明最佳的持续释放.
结论:
- 结合剂的选择和度是持续释放玻尿酸片溶解动学的关键决定因素.
- 安科姆戴II化器提供了一个更具预测性的体外评估系统,用于模拟状况.
- 2%度的木木是实现兽医配方中可控和稳定的药物释放的最佳方法.
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