"探索型肝炎作为儿科急性淋巴细胞白血病复发风险因素:来自资源有限的埃及环境的研究"
Lamiaa Fadel Alkilany1, Shaza Fadel Alkilany2, Noha Gaber3
1Virology and Immunology Unit, Cancer Biology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Journal of medical virology
|November 5, 2025
概括
在儿童急性淋巴细胞白血病 (ALL) 患者中,C型肝炎病毒 (HCV) 感染显著增加了复发风险. 早期HCV检测和管理对于改善这些脆弱儿童的治疗结果至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 肝炎C病毒 (HCV) 感染是多次输血患者的一个担忧.
- 肝炎病毒对恶性瘤结局的影响,特别是在儿科急性淋巴细胞白血病 (ALL) 中,尚不清楚.
- 了解HCV在ALL患者中的作用对于改善治疗策略至关重要.
研究的目的:
- 为了确定儿童ALL患者中HCV的发病率.
- 评估HCV感染对治疗中断,总生存率 (OS) 和儿科ALL无复发生存率 (RFS) 的影响.
- 确定HCV作为儿童ALL复发的潜在风险因素.
主要方法:
- 对2016年1月至2021年12月治疗的166名儿科ALL患者的医疗记录进行了回顾性分析.
- 定期跟踪HCV血清状况,直到2023年12月.
- 在HCV阳性和HCV阴性患者之间的复发风险,OS和RFS的统计比较.
主要成果:
- 在166名儿科ALL患者中,65人 (39.2%) 患有HCV感染.
- 与HCV阴性患者相比,HCV阳性患者的复发风险增加了6.7倍 (p < 0.001).
- 两组之间没有观察到总生存时间 (OS) 的显著差异 (p = 0.812).
结论:
- 在儿科ALL患者中发现HCV感染的高发病率.
- 感染HCV是儿童ALL复发的重要危险因素.
- 建议早期检测和治疗HCV,以改善儿科ALL患者的预后.
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