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超热vs中等风险的正常热米托辛CNMIBC:一个现实世界的回顾性队列研究
José Alberto Pereira1, Duarte Vieira-Brito2, Ana Maria Ferreira1
1Serviço de Urologia, Instituto Português de Oncologia, Coimbra.
概括
超热静脉化疗 (HIVeC) 与米托米辛C (MMC) 显示了与标准MMC相似的结果,用于中等风险的非肌肉侵入性膀癌. 艾滋病毒eC的复发时间较长,安全性和耐受性相比较.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 医疗技术 医疗技术 医学技术
背景情况:
- 超热静脉化疗 (HIVeC) 含米托米辛C (MMC) 是一种新兴的治疗中等风险的非肌肉侵入性膀癌 (Ir-NMIBC) 的方法.
- 这种方法将化疗与受控的高热症结合起来,以潜在地提高药物的疗效和免疫反应.
- 这项研究旨在将HIVeC与Ir-NMIBC的标准常温MMC进行比较.
研究的目的:
- 在Ir-NMIBC患者中比较HIVeC和标准MMC之间的瘤疗效.
- 评估和比较两种治疗方式的不良影响和安全性.
- 评估两个组的治疗遵从性和复发时间.
主要方法:
- 76名Ir-NMIBC患者的回顾性队列研究 (2020年1月 - 2023年12月).
- 患者接受了HIVeC (n=36) 或标准MMC (n=40) 膀瘤经过尿道切除后的治疗.
- 主要终点:无复发的生存率;次要:无进展的生存率,不良事件和合规性.
主要成果:
- 在36个月的随访中位数,HIVeC的复发率为38.9%,MMC为30.0%.
- 复发的中位时间较长与HIVeC (15.0vs10.5个月).
- 没有观察到无复发存活率 (62.2%与69.4%) 或无进展存活率 (100%与97.5%) 的显著差异;不良事件是轻微的和可比的.
结论:
- 与MMC一起的HIVeC在Ir-NMIBC中显示了与标准MMC相似的瘤结果.
- 艾滋病毒eC显示出更长的复发时间和类似的耐受性.
- 结果表明在选定的患者中可能使用,但由于研究的局限性,需要谨慎解释.
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