早期结构枢纽的破坏导致多发性硬化症的功能适应过早
Jan-Patrick Stellmann1,2, Adil Maarouf3,4, Mihaela Nicolescu3,4
1APHM, Hôpital de la Timone, CEMEREM, 264, Rue Saint Pierre, Marseille, 13005, France. jan-patrick.stellmann@univ-amu.fr.
Brain structure & function
|November 5, 2025
概括
多发性硬化症患者缺乏在健康衰老中看到的典型的大脑网络适应. 这可能会导致较快的神经退行和疾病进展,因为无法弥补丢失的连接.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 网络科学 网络科学
背景情况:
- 多发性硬化症 (MS) 涉及炎症和神经退行,影响大脑网络.
- 在MS中功能连接性变化的作用 (适应与反应) 仍然不清楚.
- 了解网络动态对于描述多发性硬化症病理生理学至关重要.
研究的目的:
- 研究多发性硬化患者结构和功能大脑网络的长期拓变化.
- 为了比较MS患者与不同年龄组的健康对照者的网络动态.
- 为了确定MS患者是否表现出与健康衰老相似的功能适应反应.
主要方法:
- 分析了65名多发性硬化症患者和59名对照患者的脑连接体,长达7年的时间.
- 利用扩散权重成像和静止状态MRI数据.
- 应用图形理论和枢纽中断指数来评估网络拓和连接性扰乱.
主要成果:
- 健康的个体表现出功能枢纽连接与衰老的暂时增加,补偿结构损失.
- 多发性硬化患者表现出早期的结构枢纽干扰,缺乏典型的与年龄相关的功能连接性上调.
- 多发性硬化症患者表现出早期的功能重组,但直接过渡到"耗尽"的枢纽连接状态.
结论:
- 多发性硬化症患者可能会对结构损伤产生早期的生理反应,但这会导致加速的枢纽过载.
- 在MS中缺乏与年龄相关的功能补偿可能会导致神经退行更快.
- 这种补偿机制的缺失可能是中年慢性进展的原因之一.
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