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良性多发性硬化症和30年后的长期结果
E Matas1,2, L Bau3,4, L Romero-Pinel3,4
1Multiple Sclerosis Unit, Department of Neurology, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Feixa Llarga s/n, 08907, Barcelona, Spain. ematas@bellvitgehospital.cat.
Journal of neurology
|November 5, 2025
概括
大多数患有多发性硬化症 (MS) 的患者保持良性疾病过程超过30年. 然而,即使在良性MS病例中,认知障碍也是一个重大问题.
科学领域:
- 神经学 神经学
- 临床研究 临床研究
背景情况:
- 良性多发性硬化症 (MS) 的定义是有争议的,通常仅依赖于扩展残疾状态量表 (EDSS) 和疾病持续时间.
- 其他影响患者残疾的因素在良性MS定义中并不总是被考虑.
研究的目的:
- 确定特定队列中的良性MS的流行率.
- 评估最初被归类为良性MS的患者的长期疾病过程 (20年和30年).
- 确定与维持良性MS状态相关的临床和人口因素.
主要方法:
- 符合良性多发性硬化症标准的患者的未来随访 (EDSS < 3.0 和 >= 10 年的疾病).
- 在诊断后20年和30年评估EDSS分数.
- 评估临床,放射学,疲劳,抑郁和认知变量.
主要成果:
- 在485名患者中,82人最初符合良性多发性硬化症标准.
- 20年后,75%的良性多发性硬化症患者保持EDSS≤3;30年后,60%的患者保持EDSS≤3.
- 没有临床变量预测持续良性状态. 显著的疲劳 (50%),抑郁症 (22%) 和认知障碍 (83%) 被报告的患者在30岁.
结论:
- 大多数多发性硬化症患者长期保持良性疾病状态.
- 认知障碍是长期良性多发性硬化症患者中普遍存在的问题,需要注意.
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