面向认知障碍的包容性查:在美国的种族多样化老年人中验证视觉认知评估测试
Deborah K Rose1, Gabrielle N Pfund2, Diana K Waters3
1Department of Psychiatry, Division of Behavioral Neurology and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States. debrose102@gmail.com.
Journal of cross-cultural gerontology
|November 5, 2025
概括
基于视觉的认知评估测试 (VCAT) 显示了作为阿尔茨海默病 (AD) 查的文化公正工具的承诺,与MoCA相比,反映AD生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 阿尔茨海默病 (AD) 不成比例地影响黑人/非洲裔美国人和拉丁裔人口.
- 在AD研究中的代表性不足源于传统认知评估中的偏见,例如蒙特利尔认知评估 (MoCA).
- 需要文化中立的评估来提高AD研究和临床实践的包容性.
研究的目的:
- 评估以视觉为基础的认知评估测试 (VCAT) 作为对MoCA的文化公正替代品.
- 在不同的人群中评估VCAT与MoCA的可比性.
- 为了检查VCAT得分和血p-tau217之间的关联,这是AD病理学的生物标志物.
主要方法:
- 一项涉及56个种族多样性个体的横截面研究,这些个体具有正常认知 (NC),轻度认知障碍 (MCI) 或痴呆症.
- 用VCAT和MoCA来评估认知表现.
- 线性回归模型被用来分析认知得分及其与参与者的血p-tau217水平的关联.
主要成果:
- 在所有诊断组 (NC,MCI,痴呆症) 中,VCAT得分显示与MoCA的可比性.
- 在诊断组中,VCAT和MoCA得分都存在显著差异,NC得分更高,痴呆症得分更低.
- 血p-tau217与痴呆症患者的VCAT和MoCA分数显著反相关.
结论:
- VCAT与MoCA紧密结合,为认知评估提供了一个文化敏感的替代方案.
- VCAT与血p-tau217的相关性表明它在反映潜在的阿尔茨海默病病理学方面的潜在实用性.
- 在临床环境和阿尔茨海默病的研究中,VCAT显示出增强包容性和准确性的承诺.
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