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Updated: Jan 12, 2026

Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
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Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry

Published on: July 21, 2017

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在髓瘤中抑制PIKfyve会破坏自和溶酶体,增加MHC表达和胆固醇代谢

Cecilia Bonolo De Campos1, Ruijuan He1, Tessa Josephine Pelino2

  • 1University Health Network - Princess Margaret Cancer Center, Toronto, Ontario, Canada.

Blood
|November 5, 2025
PubMed
概括

针对PIKfyve (酸-3-酸5激酶) 的新型小分子抑制剂显示出强大的抗多发性骨髓瘤 (MM) 活性. 这种方法也表明了对其他癌症的潜力,并提供了对抗药性机制的见解.

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