对于非甲状腺视神经病变的特鲁马布治疗
Tatiana R Rosenblatt1, Darren A Chen1, Carolina A Chiou1,2
1Department of Ophthalmology, Ophthalmic Plastic Surgery Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Orbit (Amsterdam, Netherlands)
|November 5, 2025
概括
在所有接受治疗的患者中,teprotumumab迅速改善并消除了与甲状腺眼病相关的压缩性视神经病变 (TED-CON). 大多数患者维持了长期的疗效,这表明teprotumumabb.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 神经外科 神经外科
背景情况:
- 甲状腺眼病相关的压缩性视神经病变 (TED-CON) 可能导致视力丧失.
- 以前的研究表明,teprotumumab可能有利于TED-CON,但时间和耐用性尚不清楚.
研究的目的:
- 为TED-CON.分析teprotumumab治疗的疗效,时间和耐久性.
主要方法:
- 对接受teprotumumab输液的患者进行了回顾性研究.
- 评估CON解决率,改善/解决时间和复发情况.
- 分析了影响解决方案和长期结果的因素.
主要成果:
- 使用TED-CON的100%的眼睛在平均1.5次注入后显示出改善.
- 在平均4次输注后,CON在78.1%的眼睛中消失.
- 在长期随访 (中位数为20.4个月) 中,尽管亡回归,但复发率很低 (15.0%).
结论:
- 在改善和解决TED-CON的过程中,teprotumumab表现出很高的疗效.
- 治疗为压缩性视神经病变提供了快速而持久的好处.
- 德普罗木马布是一种有前途的治疗选择,用于状腺视神经病变.
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