盲人的烯感知神经相关物:迈向双向皮层视觉假体的一步
Fabrizio Grani1, Cristina Soto-Sánchez1, Alfonso Rodil Doblado1
1Bioengineering Institute and Cátedra Bidons Egara, University Miguel Hernández, 03202 Elche, Spain.
Science advances
|November 5, 2025
概括
研究人员将微电极植入盲人志愿者的视觉皮层,以恢复视力. 他们发现,记录的神经活动可以准确地预测和控制视觉感知,为先进的皮层视觉假肢铺平了道路.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 眼科医生 眼科 眼科
背景情况:
- 失明是一种严重的残疾,皮质假肢有可能恢复视力.
- 以前使用电极进行刺激的人类研究在精确控制视觉感知 (色素) 方面遇到了挑战.
- 先进技术的整合对于治疗性皮质视觉假肢的成功至关重要.
研究的目的:
- 研究使用皮质内微电极阵列用于盲人视力恢复的可行性.
- 探索电刺激参数,神经活动和主观视觉体验之间的关系.
- 确定神经活动是否可以用于预测和控制皮质假肢的视觉感知.
主要方法:
- 在两个盲人志愿者的视觉皮层中植入100个电极的皮质内微电极阵列.
- 在用于诱导视觉感知的电刺激过程中,在电极周围记录神经活动.
- 分析刺激参数 (例如强度,频率) 如何影响感知值,亮度和刺激区分能力.
主要成果:
- 证明刺激参数显著影响感知值,感知亮度和区分单独刺激的最小间隔.
- 显示主观视觉体验可以从记录的神经活动中准确预测.
- 确定了利用邻近电极的神经活动来推断和控制视觉感知的潜力.
结论:
- 这项研究强调了皮质内微电极阵列在失明中恢复视力的潜力.
- 通过分析神经活动,可以准确地预测和控制视觉感知.
- 这些发现支持开发复杂的皮层视觉假肢,利用神经反来增强功能.
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