在多种外围神经上粘附的非纤维生物电子接口,用于长期的功能神经调节
Hyunmin Moon1, Bastien F G Aymon1, Jue Deng1
1Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science advances
|November 5, 2025
概括
一种新的生物粘合剂策略可以防止在周围神经上植入的生物电子设备周围形成纤维囊,从而提高它们在神经调节和疾病治疗中的长期疗效.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 材料科学 材料科学 材料科学
背景情况:
- 周围神经上的生物电子设备有望治疗疾病,但由于异物反应和纤维囊形成而面临局限性.
- 在器械神经接口的这种囊形成阻碍了器件的有效性和长寿 in vivo.
研究的目的:
- 开发一种生物粘合策略,用于在外围神经上创建非纤维生物电子接口.
- 在体内评估这些接口的长期性能和生物相容性.
主要方法:
- 采用一种新的生物粘合方法,在各种外周神经上建立接口 (头神经,迷走神经,深神经,坐骨神经,小腿神经,常神经).
- 该策略的重点是抑制免疫细胞的透,以防止纤维囊的形成.
- 具有非纤维接口的生物电子设备的疗效在自发高血压的老鼠模型中进行了评估,用于血压调节,并在长期植入神经调节的研究中进行了评估.
主要成果:
- 生物粘合策略成功地在多种外围神经上创建了非纤维的生物电子接口,长达12周.
- 该设备在4周的高血压大鼠模型中证明了持续的血压调节.
- 在12周后,在接口处观察到巨细胞,光滑肌肉活性蛋白和原蛋白的最小积累,证实了生物相容性和缺乏纤维化.
结论:
- 开发的生物粘合剂策略有效地防止生物电子设备-外围神经接口的纤维化.
- 这种方法可以实现生物电子设备的长期神经调节和治疗应用,而不会损害神经功能.
- 这些发现支持非纤维生物电子接口的潜力,用于先进的神经接口和再生医学.
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