相关实验视频

Updated: Jan 12, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

通过NFκB/Nrf-2/HO-1通路调节在CFA诱导的关节炎模型中,Bacillus clausii的治疗疗效

Fahim Hilal¹, Jehan Zeb Khan¹, Muhammad Usama Mazhar²

¹Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Biochemical and biophysical research communications

|November 5, 2025

概括

细菌克劳西表明,通过减少关节损伤和炎症,对类风湿性关节炎 (RA) 具有显著的治疗潜力. 这种益生菌通过向氧化应激和关键炎症途径,提供了一种安全的,互补的治疗选择.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
药理学药理学是指药理学的学科.

背景情况:

风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,在全球范围内影响0.24-1%.
RA 涉及失调的细胞因子信号传递,氧化应激和突炎症,导致关节的破坏.
复杂的遗传和环境因素有助于RA的发病.

研究的目的:

在类风湿性关节炎模型中研究Bacillus clausii的免疫调节和抗氧化作用.
评估Bacillus clausii作为28天的预治疗,并发和辅助治疗.

主要方法:

使用完整的弗莱恩德辅助剂 (CFA) 诱导的关节炎小鼠模型.
细菌克劳西 (Bacillus clausii) (1 × 10^8 CFU/动物/天) 是通过口服进行的.
进行了组织学,放射学和行为评估,以及对炎症标志物的分析.

主要成果:

巴西勒斯克劳西显著减少了关节损伤,关节炎得分和爪子胀.
益生菌在行为测试中表现出抗nociceptive和抗抑郁作用.
菌调节炎症通路,通过降低IFN-γ,IL-17,IL-6和p-NF-κB的调节,同时提高HO-1和Nrf-2的调节,以减少氧化应激.

结论:

细菌克劳西通过向氧化和炎症介质,在类风湿性关节炎中表现出治疗效益.
该益生菌表现出良好的安全性,没有长期毒性.
巴西勒斯克劳西可以作为一种有价值的辅助疗法,用于传统的抗关节炎治疗.

关键词:

巴西勒斯克劳西伊 (Bacillus clausii) 是一个细菌.完整的弗罗恩德的助手.印度甲素 (Indomethacin) 是一种实时的聚合酶连锁反应.类风湿性关节炎类风湿性关节炎类风湿性关节炎

更多相关视频

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Development of Recombinant Proteins to Treat Chronic Pain

Development of Recombinant Proteins to Treat Chronic Pain

Published on: April 11, 2018

相关概念视频

NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...