额叶 帕金森病患者的解剖学差异 基于冲动控制障碍特征
Richa Tripathi1, Faical Isbaine2, Ryder Dalton3
1Department of Neurology, Emory University, Atlanta, Georgia.
概括
患有帕金森病 (PD) 和冲动控制障碍 (ICD) 的患者表现出较低的上额回体体积. 这项神经成像研究突出显示了ICDPD患者明显的额叶变化.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 大脑解剖学 大脑解剖学
背景情况:
- 冲动控制障碍 (ICD) 是帕金森病 (PD) 的一个重要症状.
- 额叶区域对于决策和冲动控制途径至关重要.
- 以前的研究表明,前额叶功能与PD中的ICD之间存在联系.
研究的目的:
- 为了研究前额叶的结构变化在帕金森病患者与ICD.
- 为了比较ICD和无ICD患者的皮质厚度和体积.
- 为了确定与PD中ICD行为相关的神经解剖学差异.
主要方法:
- 来自两个中心的结构性MRI数据的回顾性分析.
- 参与者包括具有ICD (PD-ICD) 的PD患者,没有ICD (PD-nonICD) 的PD患者和健康的对照人群 (HC).
- 使用CAT12软件进行自动细分,以评估皮质厚度和体积;用于组比较的共变率的多变量分析.
主要成果:
- 与非PD-ICD和HC组相比,PD-ICD组显示出明显较小的高级前额回转 (SFG) 体积.
- 与HC相比,PD-ICD和PD-non-ICD组的轨道前回路厚度在PD-ICD和PD-non-ICD组中都减少了.
- 在PD-ICD中SFG体积的减少表明与PD患者的这一亚组相关的独特的大脑变化.
结论:
- 减少SFG体积是帕金森病中ICD的神经成像生物标志物的潜在生物标志物.
- 额叶变化,特别是在SFG中,与PD中ICD的病理生理学有关.
- 这些发现有助于理解与ICD结合的PD神经解剖学,并指导未来的研究.
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